Uncovering a key mechanism in assembly of Avian Sarcoma Virus, a relative of HIV-1

Researchers used NMR to detail how the matrix domain of the Avian Sarcoma Virus Gag protein binds to certain phospholipids. These phospholipids are vital for Gag protein binding to the plasma membrane of a cell, as the virus replicates and takes its first step toward virus formation and budding. ASV is widely used as a model to study mechanisms of HIV infection and replication.

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