An 83-year-old woman presented to our hospital with a 2-month history of progressive weight loss, weakness, and recent odynophagia. Her daughter first noticed her tongue with white plaques about 2 weeks prior to our admission (Figure 1). She was admitted to another hospital, treated for thrush, and discharged. Her tongue surface then developed a whitish exudate over the tip (Figure 2) and became more painful. Most of the history was obtained from the daughter because the patient had severe dysarthria from the tongue lesions.