Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy. Now researchers have determined the structure of this protein — a kind of ‘master switch’ for cell division — in its inactive or ‘off’ conformation.