CAR T-cell therapy may be harnessed to treat heart disease

CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients’ own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. Researchers at Penn Medicine used genetically modified T cells to target and remove activated fibroblasts that contribute to the development of cardiac fibrosis — a scarring process found in most forms of heart disease that results in heart stiffness and decreased function of the heart.

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