Psychiatric adverse drug reactions (ADRs) have been reported with a diverse range of medicines used to treat physical illness. Whereas some are mild (e.g. transient sleep disturbances), others are severe (e.g. psychosis) and warrant discontinuation of the suspected causal agents. Some reactions are predictable, while others are unpredictable. The mechanism by which they are mediated is often unclear. It is essential that serious psychiatric ADRs observed during routine clinical practice in the UK are reported via the Yellow Card reporting scheme as relatively uncommon ADRs may only be detected through post-marketing surveillance in the wider population.