The collagen vascular diseases can be challenging for the internist and are associated with higher utilization of resources and less favorable outcomes among patients admitted to the inpatient medicine services.1 In this context, the acquisition of proficiency in recognizing a range of disease manifestations, common and uncommon, and familiarity with the appropriate therapeutic interventions are critical skills to be enhanced.2 In this report, we highlight the challenging diagnostic and therapeutic predicament, centered around daily high spiking fevers, of an enigmatic patient whose hospital course achieved a favorable outcome when the etiology of the fever was reformulated and managed in a novel manner.