The US Food and Drug Administration recently granted an approved indication for the first fixed-dose combination antihypertensive (amlodipine) and nonsteroidal…
Marijuana’s Effects on Brain Structure and Function: What Do We Know and What Should We Do? A Brief Review and Commentary
The recent US Food and Drug Administration approval of the marijuana constituent cannabidiol as safe and effective for treatment of…
Diagnostic and Management Dilemma: Massive Hemoptysis from Severe Mitral Stenosis
Severe hemoptysis in a critically ill patient must prompt rapid development of a broad differential. We present an unusual case…
Asking How Our Patients Understand Addiction
When the President’s Commission on Combating Drug Addiction and the Opioid Crisis declares “addiction [a] chronic relapsing disease of the…
Bilateral Breast Ulcers: Granulomatosis with Polyangiitis
An investigation into the patient’s unusual dermatologic symptoms identified an underlying autoimmune disease. Fourteen days after breast-reduction surgery, the patient,…
Sarcoidosis Presenting as Isolated Anasarca and Hypercalcemia
A 62-year-old woman presented to clinic for a second evaluation. Previously healthy, she initially presented for care several months earlier…
Spironolactone and Outcomes in Older Patients with Heart Failure and Reduced Ejection Fraction
The efficacy of mineralocorticoid receptor antagonists or aldosterone antagonists in heart failure with reduced ejection fraction (HFrEF) is well known.…
The Computerized ECG: Friend and Foe
Computerized interpretation of the electrocardiogram (ECG) began in the 1950s when conversion of its analog signal to digital form became…
Lift Then Shift: Thyrotoxic Periodic Paralysis
A transient paralysis was precipitated by thyroid dysfunction. The patient, a 29-year-old man, woke up with diffuse muscle pain and…
Down the Rabbit Hole: Cutaneous Tuberculosis
The term “going down the rabbit hole,” based on Lewis Carroll’s Alice’s Adventures in Wonderland, is a metaphor for an…