New research describes a mechanism in a mouse model of asthma that supports the hygiene hypothesis — researchers found that infant mice need a higher exposure to a bacterial endotoxin, compared to adult mice, to avoid developing asthma-like reactions to house dust mites. The hygiene hypothesis suggests that decreased exposure to microbial products in industrialized nations is the main driver of increased allergic airway disease.
Mechanism for impaired allergic inflammation in infants may explain hygiene hypothesis
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