New evidence points to a key role for a molecular switch called VGLL3 in autoimmune diseases, and the major gap in incidence between women and men. Building on past research showing that women have more VGLL3 in their skin cells than men, a team studied it further in mice. They show that having too much VGLL3 in skin cells pushes the immune system into overdrive, leading to an autoimmune response and symptoms similar to lupus.
Discovery may help explain why women get autoimmune diseases far more often than men
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