Epicardial Adipose Tissue Inflammation Can Cause the Distinctive Pattern of Cardiovascular Disorders Seen in Psoriasis

Psoriasis is a systemic inflammatory disorder that can target adipose tissue; the resulting adipocyte dysfunction is manifest clinically as the metabolic syndrome, which is present in ≈20–40% of patients. Epicardial adipose tissue inflammation is likely responsible for a distinctive pattern of cardiovascular disorders, consisting of1: accelerated coronary atherosclerosis leading to myocardial infarction,2 atrial myopathy leading to atrial fibrillation and thromboembolic stroke, and3 ventricular myopathy leading to heart failure with a preserved ejection fraction.