A clinical perspective article reviews various imaging manifestations of electronic nicotine delivery systems such as e-cigarettes, vape pens, and hookah tanks. Despite the lack of a standardized case definition for vaping-associated lung injury, the radiologist may be the first person to prompt the clinical team to ask about relevant exposures like hypersensitivity pneumonitis, diffuse alveolar hemorrhage, acute eosinophilic pneumonia, organizing pneumonia, lipoid pneumonia, and giant cell interstitial pneumonia.