A new study shows the first evidence supporting a role for glucagon-like peptide-1 (GLP-1) receptor agonists in opioid reinforcement and analgesic responses. Using recently established models of opioid-taking and -seeking behaviors in rats, researchers have shown that systemic administration of the GLP-1 receptor agonist exendin-4 reduced oxycodone self-administration and the reinstatement of oxycodone-seeking behavior, an animal model of relapse.
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