Constipation affects about half of patients with advanced illness and nearly all terminally ill patients receiving opioids. Constipation can be very distressing, leading to abdominal pain/distension, anorexia, nausea/vomiting, faecal impaction, intestinal obstruction, urinary retention and incontinence; reducing quality of life. A thorough assessment is critical to diagnose it, assess its severity, impact and associated symptoms, and find the cause. Management includes explanations to the patient/family, treating reversible causes (where appropriate) and optimizing non-pharmacological treatments and drugs.