Subacute thyroiditis, also termed as De Quervain thyroiditis is a self-limited and transient inflammatory disorder of the thyroid gland1. Although it is thought to be a virus-associated syndrome, the causal agent is rarely identified2. Despite the strong erythroid tropism of Erythrovirus B19 (EVB19), infection is also associated with thyroid disorders3. We describe a rare case of EVB19-related subacute thyroiditis.