MINOCA in a Patient with Sickle Cell Disease

Sickle cell disease is an inherited disorder in which microvascular occlusion causes complications across multiple organ systems. Acute myocardial infarction is increasingly recognized as a feature of sickle cell disease.1 Acute myocardial infarction is often clinically overshadowed by more substantial presentations of vasoocclusion such as musculoskeletal pain.2 However, one-third of adults with sickle cell disease suffer from left ventricular dysfunction that may be related to recurrent micro-injury, which may have begun years prior to a heart failure presentation.