Genetic renal disorders

Genetic disorders of renal structure and function are recognized causes of end-stage renal disease (ESRD) requiring renal replacement therapy. A family history of haematuria, urinary tract infection or ESRD can prompt the clinician to consider an underlying renal genetic disorder. In practice, the most common inherited renal condition is autosomal dominant polycystic kidney disease (ADPKD), characterized by multiple kidney cysts associated with hypertension and later progression to chronic kidney disease (CKD).