Coccidioidomycosis (Valley fever) is an infection caused by the soil-inhabiting molds, Coccidioides immitis or Coccidioides posadasii.2 Southern Arizona is one of the endemic region for this fungus, posing a unique challenge to the patients residing in this area. Of the 150,000 new coccidioidomycosis infections occuring annually in the United States, approximately 1% are disseminated infections and one third of these cases are often fatal.3–5