Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of bacteremia and of metastatic infections such as endocarditis, resulting in significant morbidity and mortality.1 We present a patient with persistent MRSA bacteremia despite antibiotic therapy. Although initial TEE was unremarkable, follow-up TEE confirmed infectious aortitis, illustrating the importance of repeated examination and imaging.