Autoimmune hepatitis and overlap syndrome

Autoimmune hepatitis (AIH) is an acute or chronic liver disease that causes significant inflammation at a cellular level and leads to cirrhosis if left untreated. The basis of diagnosis is increased liver enzymes and immunoglobulins with positive autoantibodies and necroinflammatory changes on liver biopsy. Clinical presentations can vary. Asymptomatic patients may only have raised liver enzymes detected on routine testing, the other extreme of presentation being represented by fatigue, jaundice and liver failure.