MINOCA in patient with Sickle Cell Disease

Sickle cell disease is an inherited disorder in which microvascular occlusion causes complications across multiple organ systems. Acute myocardial infarction is increasingly recognized as a feature of sickle cell disease.1 Acute myocardial infarction is often clinically overshadowed by more dramatic presentations of vaso-occlusion such as musculo-skeletal pain2. However, one third of adults with sickle cell disease suffer from left ventricular dysfunction that may be related to recurrent micro-injury, which may have begun years before a heart failure presentation3,4.