Approximately 5% of women experience two or more miscarriages, a condition known as recurrent pregnancy loss (RPL). Although genetic testing is important for evaluating RPL, current tests have revealed shortcomings in clinical practice. A report describes a new high-resolution melting analysis-based test that is accurate, rapid, cheap, and easy to perform. When used prior to other tests, it improved cost-effectiveness by 30%, an important consideration in areas with limited healthcare resources.