Cardiorespiratory Fitness, Body Mass Index and Insulin Resistance in Healthy Adults

I read the article by Clarke et al1 with interest. The combination of impaired fasting glucose (100-125 mg/dL) and elevated fasting triglycerides (≥150 mg/dL) was used as a marker of insulin resistance, and odds ratio for insulin resistance increased as body mass index (BMI) reached higher levels, especially in women. The authors concluded that poor fitness was significantly associated with the risk of insulin resistance, and obese individuals, particularly women, might benefit from the greatest absolute risk reduction by achieving moderate fitness.