How plague pathogens trick the immune system

Yersinia have spread fear and terror, especially in the past, but today they have still not been completely eradicated. The bacteria inject various enzymes, including YopO, into the macrophages of the immune system. There it is activated and prevents the defense cells from enclosing and digesting the plague bacteria. Using the latest methods, scientists have now deciphered how YopO changes its shape and thus contributes to confusing the immune system.

Facial plastic surgery in men enhances perception of attractiveness, trustworthiness

In the first of a kind study, plastic surgeons found that when a man chose to have facial plastic surgery, it significantly increased perceptions of attractiveness, likeability, social skills, or trustworthiness. The study did not show a significant impact on perceptions of gender (masculinity), whereas a similar study performed with women in 2015 showed a significant increase in ratings of femininity.

New sensor could shake up earthquake response efforts

An optical sensor could speed up the time it takes to evaluate whether buildings are safe to occupy after a major earthquake. After four years of extensive peer-reviewed research and simulative testing, the Discrete Diode Position Sensor (DDPS) will be deployed for the first time this summer in a multi-story building — which sits adjacent to the Hayward Fault, considered one of the most dangerous faults in the United States.

Successful T cell engineering with gene scissors

The idea of genetically modifying a patient’s own immune cells and deploying them against infections and tumors has been around since the 1980s. But to this day modified T cells are still not as effective as natural T cells and have been only been of limited clinical value. Using the new CRISPR-Cas9 gene editing tool, a team (TUM) has now engineered T cells that are very similar to physiological immune cells.