Net Clinical Benefit of Non-Vitamin K Antagonist vs Vitamin K Antagonist Anticoagulants in Elderly Patients with Atrial Fibrillation

The risks of thromboembolic and hemorrhagic events in patients with atrial fibrillation both increase with age; therefore, net clinical benefit analyses of anticoagulant treatments in the elderly population are crucial to guide treatment. We evaluated the 1-year clinical outcomes with non-vitamin-K antagonist and vitamin K antagonist oral anticoagulants (NOACs vs VKAs) in elderly (≥75 years) patients with atrial fibrillation in a prospective registry setting.

Placentas adapt when mothers have poor diets or low oxygen during pregnancy

Researchers have discovered the placenta regulates how much oxygen and nutrients it transports to babies during challenging pregnancies in the first study of its kind. The placenta is one of the least understood human organs and it is notoriously difficult to study. This new research focused on analyzing the placental mitochondria and it is hoped the new findings could lead to tests to determine whether a mother’s placenta is functioning properly.

Fighting deadly drug resistant bacteria in intestines with new antibiotic

Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time, particularly in Australia’s ageing population. But when doses of a new antibiotic called Ramizol were given to hamsters infected with a lethal dose of the bacteria, a significant proportion of hamsters survived the infection.