There have been many published studies describing the current epidemic of burnout among physicians, but there are far fewer with solutions to the problem. Different approaches have been tried, but few have shown a significant impact on burnout or improved wellness among physicians. Nevertheless, the few published studies of solutions present some promising strategies for addressing the problem. The most effective interventions include leadership or system-wide changes. A systematic review and metanalysis showed that interventions directed at individuals reaped small benefits that were often increased in the setting of system-wide organizational approaches.