CRISPR joins battle of the bulge, fights obesity without edits to genome

A weighty new study shows that CRISPR therapies can cut fat without cutting DNA. Researchers describe how a modified version of CRISPR was used to ramp up the activity of certain genes and prevent severe obesity in mice with genetic mutations that predispose them to extreme weight gain. Importantly, the researchers achieved long-lasting weight control without making a single edit to the genome.

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