Peptic ulcer disease continues to be a source of significant morbidity and mortality worldwide. Approximately two-thirds of patients found to have peptic ulcer disease are asymptomatic. In symptomatic patients, the most common presenting symptom of peptic ulcer disease is epigastric pain, which may be associated with dyspepsia, bloating, abdominal fullness, nausea, and/or early satiety. Most cases of peptic ulcer disease are associated with H. pylori infection and/or the use of non-steroidal anti-inflammatory drugs (NSAIDs).