New target for chronic pain: Shape of structure that nerve cells use to sense cold

People are great at detecting cold temperatures and the cool sensation induced by natural substances like menthol. And while the same protein in nerve cells is responsible for sensing both, it isn’t entirely clear how it works. Now, a team of researchers has determined the structure of this protein when it is bound to menthol. The findings could pave the way for therapies to treat chronic pain and migraine.

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